Sparks expertise across research, clinical, regulatory and manufacturing builds on a legacy of innovation and excellence in gene therapy established by Sparks team while at The Childrens Hospital of Philadelphia Center for Cellular and Molecular Therapeutics. Spark's development program for hemophilia B,SPK-FIX, is advancing proprietary, bio-engineered adeno-associated virus (AAV) vectors that deliver a high-activity Factor IX gene to the liver. Spark plans to leverageSPK-RPE65to address a broad spectrum of blinding conditions, and also has established a pipeline of gene therapy candidates to treat hematologic and neurodegenerative disorders. "The collaboration also marks another milestone for Spark, following our recent clinical and regulatory progress and key leadership hires.". Our mission at Spark Therapeutics is to challenge the inevitability of genetic disease by discovering, developing and delivering potential treatments in ways unimaginableuntil now. To learn more visit www.sparktx.com. from 8 AM - 9 PM ET. Type Public Founded 2013 HQ Environmental, Social and Governance (ESG), HVAC (Heating, Ventilation and Air-Conditioning), Machine Tools, Metalworking and Metallurgy, Aboriginal, First Nations & Native American, www.sparktx.com/pipeline/hematologic-disorders, http://www.prnewswire.com/news-releases/spark-therapeutics-announces-gene-therapy-collaboration-in-hemophilia-b-with-pfizer-inc-300005849.html. Leading gene therapy Company will partner with established market leader to develop a potential new treatment paradigm for hemophilia B. PHILADELPHIA, Dec. 8, 2014 /PRNewswire/ -- Spark Therapeutics, a late-stage gene therapy company developing treatments for debilitating genetic diseases, announced today that it has entered into a global collaboration with Pfizer Inc. for the development and potential commercialization of SPK-FIX, a development program advancing proprietary, bio-engineered adeno-associated virus (AAV) vectors for the potential treatment of hemophilia B. Associate Professor of Neurology. philadelphia, oct. 22, 2013 /prnewswire/ -- spark therapeutics, a new, fully integrated company developing gene-based medicines for a wide range of debilitating diseases, announced today it has. Spark Therapeutics will be responsible for the supply of voretigene neparvovec worldwide under a separate manufacturing and supply agreement with Novartis. The Spark team was among the first to demonstrate human clinical proof of concept in two distinct organ systemsthe eye and the liverestablishing a strong foundation for the company's current programs, and has clinical experience in 15 studies across diverse genetic and non-genetic diseases and five distinct routes of administration. To learn more please visit the Spark website at www.sparktx.com/pipeline/hematologic-disorders. Spark Therapeutics revenue is $93.5M annually. We are a force of over 90,000 people working together across more than 100 countries. It has a pipeline of product candidates targeting multiple rare blinding conditions, hematologic disorders and neurodegenerative diseases. To learn more, visitwww.sparktx.com. Spark Therapeutics, Inc. 3737 Market Street Philadelphia, PA 19104 Phone: 1-855-SPARKTX / +1 215-220-9300 2022 Spark Therapeutics, Inc. P-RPE65-US-450002-10 Please be aware that we do not take any responsibility for accessing such information which may not comply with any legal process, regulation, registration or usage in the country of your origin. The company's product candidates are in the field of retina-directed gene therapies, liver-directed gene therapies, and central nervous . For more information on Spark Therapeutics and its clinical pipeline, including SPK-FIX, please visit www.sparktx.com. $64.7 M FY, 2018 Market Capitalization $4.4 B 2019-12-17 Company summary Overview Spark Therapeutics is a gene therapy company. "Filtering down to just Philadelphia proper does reveal that . Spark Therapeutics, Inc. PHILADELPHIA, Nov. 6, 2014 /PRNewswire/ -- Spark Therapeutics, a late-stage gene therapy company developing treatments for debilitating genetic diseases, announced today that its lead product . The Gene Therapy Medicinal Products (GTMP) Market research report includes Market segmentation and overlays shadow upon the leading market players highlighting the favourable competitive landscape and trends prevailing over the years. AAPL, FB, TWTR), Total amount raised across all funding rounds, Total number of lead investment firms and individual investors, Total number of investment firms and individual investors, Announced Date: Date that the Funding Round was publicly announced, Transaction Name: Auto-generated name of transaction (e.g. High, M.D, a gene therapy pioneer who has served as the director of the CCMT since its inception. Which investors participated in the most funding rounds? "This agreement reinforces Pfizer's longstanding commitment to the hemophilia community. SaaS, Android, Cloud Computing, Medical Device). Spark Therapeutics uses 27 technology products and services including HTML5, Google Analytics, and jQuery, according to G2 Stack. Spark Therapeutics has 368 employees, and the revenue per employee ratio is $254,076. The Company focuses on treating orphan diseases. About Spark Therapeutics. We have built a fully integrated company, combining our proprietary adeno-associated viral (AAV) gene therapy platform with excellence in R&D, manufacturing and . Their latest funding was raised on May 27, 2014 from a Series B round. Sep 2015 - May 20171 year 9 months. Spark Therapeutics Launched with $50 Million in Financing to Advance Late- and Mid-Stage Gene Therapy Programs with Clinical Proof of Concept . About Spark Therapeutics Spark Therapeutics is developing potentially curative, one-time gene therapy products to transform the lives of patients and re-imagine the treatment of debilitating diseases. Head of Corporate Security. WhatsApp acquired by Facebook). PHILADELPHIA, Dec. 8, 2014 /PRNewswire/ -- Spark Therapeutics, a late-stage gene therapy company developing treatments for debilitating genetic diseases, announced today . Description. Spark's initial focus is on treating orphan diseases where no, or only palliative therapies, exist. Spark Therapeutics is focused on the development of treatments for genetic diseases. October was an important month for Spark Therapeutics . Hemophilia Bis a rare genetic blood disorder that affects approximately 4,000 males in the U.S. and 26,000 malesworldwide. Its products include LUXTURNA (voretigene neparvovec) for the treatment of patients with confirmed biallelic RPE65 mutation-associated retinal dystrophy and viable retinal cells. Notably, Spark has exclusive rights to commercialize CHOP's proprietary manufacturing technology and will use clinical . Which funding types raised the most money? After extensive research and analysis, Zippia's data science team found the following key financial metrics. Environmental, Social and Governance (ESG), HVAC (Heating, Ventilation and Air-Conditioning), Machine Tools, Metalworking and Metallurgy, Aboriginal, First Nations & Native American. Spark Therapeutics (NASDAQ:ONCE), a fully integrated gene therapy company dedicated to challenging the inevitability of genetic disease, and Pfizer (NYSE:PFE), today announced that, with a cumulative follow-up of more than 18 patient years of observation (5 to 121 weeks), all 15 participants in the ongoing Phase 1/2 clinical trial of investigational SPK-9001 for severe or moderately severe . Name of the organization that made the acquisition, Stock ticker symbol (e.g. Spark's hemophilia B program has the potential to build on our leading hemophilia portfolio and could offer patients with this bleeding disorder a potential new treatment option.". (Animal Production and Products) Association of Research Directors (ARD) 2013 . The founding team includes scientists who have led the advancement of gene therapy over the past two decades, establishing human proof of concept of the expression of gene. The company's expertise across research, clinical, regulatory and manufacturing builds on a legacy of innovation and excellence in gene therapy established by Spark's team while at The Children's Hospital of Philadelphia Center for Cellular and Molecular Therapeutics. The organisation is a fully integrated, commercial company committed to discovering, developing and delivering gene therapies for genetic diseases, including inherited retinal disorders, haemophilia, lysosomal storage disorders and neurodegenerative diseases. Active, Closed, Last funding round type (e.g. Trademark applications show the products and services that Spark Therapeutics is developing and marketing. Our robust pipeline includes a Phase 3 program in blindness due to mutations in the RPE65 gene and a Phase 1/2 program in hemophilia B, as well as preclinical programs to address neurodegenerative diseases and other retinal degenerative diseases and hematologic disorders. Spark Therapeutics's new tradmarks suggest it is investing in R&D . What is Spark Therapeutics's Revenue? Media Inquiries: Jessica Rowlands 202-729-4089 [emailprotected], Cision Distribution 888-776-0942 Spark Therapeutics' relocation gives more space to the laboratory functions with approximately 22,700-square-feet of lab space, 14,800-square-feet of office/meeting/amenity space, and an additional11,200-square-feet of building support and core on the second floor and 9,000-square-feet on the garden level. Spark Therapeutics was founded in 2013 and became a Member of the Roche Group in 2019. Philadelphia, Pennsylvania, United States . The Company focuses on treating orphan diseases. "Gene-based medicines are among the most complex therapeutics ever developed," said Dr. High. Mutations in the RPE65 gene lead to reduced or absent levels of RPE65 isomerohydrolase activity, blocking the visual cycle and resulting in progressive vision loss and ultimately, blindness [1]. Angel - Uber), Number of Investors: Total number of Investors in a Funding Round, Money Raised: Amount of money raised in Funding Round, Lead Investors: Name of the investor who led the investment in the funding round, The date when the Organization went public, Investor Name: Name of the investor who participated in the Investment, Lead Investor: This field indicates whether an investor led/organized the investment, Funding Round: Name of the funding round where the Investment is made, Partners: Name of the individual who led a funding round for his/her firm, Acquiree Name: Name of the acquired organization, Announced Date: Date the acquisition was announced, Transaction Name: Auto-generated name of transaction (e.g. "The creation of Spark is the culmination of a decade-long commitment by CHOP and our founding team to drive the field of gene therapy forward during a time when many in the industry had moved away," said Jeffrey D. Marrazzo, co-founder, president and chief executive officer of Spark Therapeutics. Spark has rights to a proprietary manufacturing platform that has a track record supporting clinical studies across diverse therapeutic areas and routes of administration. When typing in this field, a list of search results will appear and be automatically updated as you type. This rating has been stable . Spark Therapeutics is an equal opportunity employer. Iowa City, Iowa, United States. Spark's integrated gene therapy platform builds on two decades of research, development and manufacturing at The Children's Hospital of Philadelphia, including human trials conducted across diverse therapeutic areas and routes of administration. Spark Therapeutics has an overall rating of 4.4 out of 5, based on over 72 reviews left anonymously by employees. Spark Therapeutics, Inc. Feb 2020 - Dec 2020 11 months. About Spark TherapeuticsSpark Therapeutics is developing potentially curative, one-time gene therapy products to transform the lives of patients and re-imagine the treatment of debilitating diseases. AAV has been demonstrated in clinical studies to be a safe and effective vehicle for the delivery of genetic material into targeted cells and provides unique advantages over alternative delivery approaches. R&D in Biotech, Environmental and various industries (no marketing product yet) Tags Biotechnology, Healthcare Venture Deals, Healthcare IPO Companies managed Acquired/Merged Spark Therapeutics Headquarters 3737 Market Street Suite 1300 Philadelphia, PA 19104 US (888) 772-7560 info@sparktx.com Web Site N/A Milestones Related Companies The founding team includes scientists who have led the advancement of gene therapy . Detailed information on company financials and operating reports can be found here: . If successful, gene therapy in hemophilia B would eliminate or reduce the need for regular infusions of clotting factor, enabling physicians to provide comprehensive, accessible treatment to all hemophilia B patients, potentially including those with inhibiting antibodies. "We believe Pfizer is the ideal partner for our hemophilia B program. Under the terms of the agreement, Spark will receive an upfront payment of $20 million and will be eligible for additional development and commercialization milestone payments of up to $260 million for multiple hemophilia B product candidates that may be developed under the collaboration. Spark Therapeutics is developing potentially curative, one-time gene therapy products to transform the lives of patients and re-imagine the treatment of debilitating diseases. Many of the CCMT's leaders will assume management roles within Spark or engage with the company as scientific advisors, including Katherine A. . It has a pipeline of product candidates targeting multiple rare blinding conditions, hematologic disorders and neurodegenerative diseases. Which types of acquisition does this organization make most frequently. Spark Therapeutics is actively using 64 technologies for its website, according to BuiltWith. The companies will work together on a worldwide basis with the aim of bringing an important investigational therapy to patients. Spark is entitled to receive double-digit royalties based on global product sales. Contents 1 History 2 Products and pipeline 2.1 Voretigene neparvovec 2.2 Fidanacogene elaparvovec 2.3 SPK-8011 2.4 SPK-7001 2.5 SPK-3006 SPK-FIX leverages a long track record of hemophilia B gene therapy research conducted by Spark and its founding scientific team which, in prior clinical trials, has demonstrated safety and proof-of-concept in expressing Factor IX in the liver. Find company research, competitor information, contact details & financial data for Spark Therapeutics, Inc. of Philadelphia, PA. Get the latest business insights from Dun & Bradstreet. Spark Therapeutics, Inc. insights Based on 10 survey responses What people like Ability to learn new things Time and location flexibility Fair pay for job Areas for improvement Energizing work tasks Sense of belonging Overall satisfaction The best job I'll ever have Quality Control Analyst (Former Employee) - Philadelphia, PA - February 20, 2022 Spark will assume control over two gene therapy clinical trials: a Phase 3 study for inherited blindness caused by mutations of the RPE65 gene and a Phase 1/2 study for hemophilia B. The founding team includes scientists who have led the advancement of gene therapy over the past two decades, establishing human proof of concept of the expression of . Spark Therapeutics has acquired Genable Technologies Ltd. on Mar 7, 2016. The average Spark Therapeutics salary ranges from approximately $93,180 per year for a Research Associate to $158,235 per year for a Senior Scientist.The average Spark Therapeutics hourly pay ranges from approximately $44 per hour for a Research Associate to $66 per hour for a Project Manager.Spark Therapeutics employees rate the overall compensation and benefits package 4.6/5 stars. Posted 2w ago . Get company contacts "Their vision and long-term dedication have enabled us to effectively address many of the key challenges facing the field and to emerge with one of the industry's most robust clinical-stage gene therapy pipelines; as well as exclusive rights to commercialize a proprietary manufacturing platform, supply from a world-class manufacturing facility and a founding team with a proven track record of executing safe and effective gene therapy trials for nearly two decades.

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